Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
نویسندگان
چکیده
منابع مشابه
Role of plasmalemmal caveolae in signal transduction.
Caveolae are specialized plasmalemmal microdomains originally studied in numerous cell types for their involvement in the transcytosis of macromolecules. They are enriched in glycosphingolipids, cholesterol, sphingomyelin, and lipid-anchored membrane proteins, and they are characterized by a light buoyant density and resistance to solubilization by Triton X-100 at 4°C. Once the identification o...
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Biochemical and cell fractionation studies suggest caveolae contain functionally organized sets of signaling molecules that are capable of transmitting specific signals to the cell. It is not known, however, whether any signals actually originate from caveolae in living cells. To address this question, we have engineered the calcium sensor yellow cameleon so that it is targeted either to the pl...
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1Laboratory for Drug Design and Synthesis, Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda Punjab 151001, India 2Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, 720 BRB-II/III, 421 Curie Boulevard Philadelphia, PA 19104-6160, USA 3The Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, ...
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Herbal medicine, botanical medicine, phytotherapy, alternative medicine or, complimentary medicine are terms used to describe the science of using plant-based materials to treat specific symptoms or diseases. People have strong belief that natural remedies are perfectly safe. Because we have strong ties to traditional culture we use herbs and spices on daily basis. Plants are an abundant natura...
متن کاملStrategy for research of new pharmacologically active molecules from plants for the treatment of pathologies
Herbal medicine, botanical medicine, phytotherapy, alternative medicine or, complimentary medicine are terms used to describe the science of using plant-based materials to treat specific symptoms or diseases. People have strong belief that natural remedies are perfectly safe. Because we have strong ties to traditional culture we use herbs and spices on daily basis. Plants are an abundant natura...
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ژورنال
عنوان ژورنال: Annual Review of Pharmacology and Toxicology
سال: 2008
ISSN: 0362-1642,1545-4304
DOI: 10.1146/annurev.pharmtox.48.121506.124841